Hexproof prevents targeting, making removing this beast a difficult task for any opponent, and Annihilator 2 forces other players to sacrifice two of their permanents whenever the Breaker of Creation sets its sights on them and attacks
Ruination is your best land destruction spell
To that end, I think the decision will ultimately come down to how relevant the sacrifice ability is on the card
At the beginning of your upkeep, you may untap target creature and gain control of it until end of turn
When I wrote my deep dive on Urtet, Remnant of Memnarch, it was incredibly expensive, but its good to see the price has come way, way down these days
You may well have to pick some things you don't want to and likely over things you did want and then shoehorn these random life gain things into your deck that you otherwise don't need or have better options you would rather have in the slot